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Le. First Aid USMLE Step 1. Pharmacology. 30e. 2020.

CONTENTS
PHARMACOKINETICS & PHARMACODYNAMICS
Enzyme kinetics
Michaelis-Menten kinetics
Lineweaver-Burk plot
Pharmacokinetics
Bioavailability (F)
Volume of distribution (V d )
Clearance (CL)
Half-life (t 1/2 )
Dosage calculations
Drug metabolism
Elimination of drugs
Zero-order elimination
First-order elimination
Urine pH and drug elimination
Weak acids
Weak bases
pKa
Efficacy vs potency
Efficacy
Potency
Receptor binding
Therapeutic index
Types of drug interactions
AUTONOMIC DRUGS
Autonomic receptors
Acetylcholine receptors
Micturition control
G-protein–linked second messengers
Autonomic drugs
Cholinomimetic agents
Cholinesterase inhibitor poisoning
Muscarinic antagonists
Atropine
Sympathomimetics
Norepinephrine vs isoproterenol
Sympatholytics (α2-agonists)
α-blockers
β-blockers
Phosphodiesterase inhibitors
TOXICITIES & SIDE EFFECTS
Ingested seafood toxins
Beers criteria
Specifc toxicity treatments
Drug reactions—cardiovascular
Drug reactions—endocrine/reproductive
Drug reactions—gastrointestinal
Drug reactions—hematologic
Drug reactions—muscskel/skin/con
Drug reactions—neurologic
Drug reactions—renal/genitourinary
Drug reactions—respiratory
Drug reactions—multiorgan
Drugs affecting pupil size
Cytochrome P-450 interactions selected
Sulfa drugs
MISCELLANEOUS
Drug names
Biologic agents