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Dudek. HY Cell & Molecular Biology. 3e. 2010.

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1 Chromosomal DNA
I. The Biochemistry of Nucleic Acids
II. Levels of DNA Packaging
III. Centromere
IV. Heterochromatin
V. Euchromatin
VI. Studying Human Chromosomes
VII. Staining of Chromosomes
VIII. Chromosome Morphology
IX. DNA Melting Curve
2 Chromosome Replication
I. General Features
II. The Chromosome Replication Process
III. DNA Topoisomerases
IV. The Telomere
V. DNA Damage
VI. DNA Repair
VII. Clinical Considerations
VIII. Summary of Chromosome Replication Machinery
3 Meiosis and Genetic Recombination
I. Meiosis
II. Genetic Recombination
4 The Human Nuclear Genome
I. General Features
II. Protein-Coding Genes
III. RNA-Coding Genes
IV. Epigenetic Control
V. Noncoding DNA
5 The Human Mitochondrial Genome
I. General Features
II. The 13 Protein-Coding Genes
III. The 24 RNA-Coding Genes
IV. Other Mitochondrial Proteins
V. Mitochondrial Diseases
6 Protein Synthesis
I. General Features
II. Transcription
III. Processing the RNA Transcript into mRNA
IV. Translation
V. Clinical Considerations
7 Control of Gene Expression
I. General Features
II. Mechanism of Gene Expression
III. The Structure of DNA-Binding Proteins
IV. Other Mechanisms of Gene Expression
V. The Lac Operon
VI. The trp Operon
8 Mutations of the DNA Sequence
I. General Features
II. Silent (Synonymous) Mutations
III. Non-Silent (Nonsynonymous) Mutations
IV. Loss of Function and Gain of Function Mutations
V. Other Types of Polymorphisms
9 Proto-Oncogenes, Oncogenes, and Tumor-Suppressor Genes
I. Proto-Oncogenes and Oncogenes
II. Tumor-Suppressor Genes
III. Hereditary Cancer Syndromes
10 The Cell Cycle
I. Mitosis
II. Control of the Cell Cycle
11 Molecular Biology of Cancer
I. The Development of Cancer (Oncogenesis)
II. The Progression of Cancer
III. Signal Transduction Pathways
12 Cell Biology of the Immune System
I. Neutrophils (Polys, Segs, or PMNs)
II. Eosinophils
III. Basophils
IV. Mast Cells
V. Monocytes
VI. Macrophages (Histiocytes; Antigen-Presenting Cells)
VII. Natural Killer CD16 + Cell
VIII. B Lymphocyte
IX. T Lymphocyte
X. Immune Response to Exogenous Protein Antigens
XI. Immune Response to Endogenous Antigens (Intracellular Virus or Bacteria)
XII. Cytokines
13 Molecular Biology of the Immune System
I. Clonal Selection Theory
II. The B Lymphocyte (B Cell)
III. The T Lymphocyte (T Cell)
IV. Clinical Considerations
V. Disorders of Phagocytic Function
VI. Systemic Autoimmune Disorders
VII. Organ-Specific Autoimmune Disorders
14 Molecular Biology Techniques
I. Action of Restriction Enzymes
II. Electrophoresis
III. The Enzymatic Method of DNA Sequencing
IV. Southern Blotting and Prenatal Testing for Sickle Cell Anemia
V. Isolating a Human Gene by DNA Cloning
VI. Construction of cDNA Library
VII. Polymerase Chain Reaction
VIII. Producing a Protein from a Cloned Gene
IX. Site-Directed Mutagenesis and Knockout Animals
X. Northern Blot (mRNA)
XI. Western Blot (Protein)
XII. Human Immunodeficiency Virus (HIV) Structure
XIII. Ligase Chain Reaction (LCR)
XIV. Flow Cytometry
15 Identification of Human Disease Genes
I. General Features
II. Identification of a Human Disease Gene Through a Chromosome Abnormality
III. Identification of a Human Disease Gene Through Pure Transcript Mapping
IV. Identification of a Human Disease Gene Through Large Scale DNA Sequencing
V. Identification of a Human Disease Gene Through Comparison of Human and Mouse Maps
16 Gene Therapy
I. Gene Therapy
II. Ex Vivo and In Vivo Gene Therapy
III. Integration into Host Cell Chromosomes or as Episomes
IV. Viral Vectors Used in Gene Therapy
V. Nonviral Vectors Used in Gene Therapy
Appendix 1: The Genetic Code
Appendix 2: Amino Acids
Appendix 3: Chromosomal Locations of Human Genetic Diseases